The objective for the e-Patch™ was to combine all the user advantages of transdermal patches with the accuracy and flexibility of conventional ambulatory pumps. The result is a miniature device that offers improved patient compliance and flexible delivery profiles over an extremely wide range of clinical applications. The e-Patch is either pre-filled or filled at point of care. Drug container is pharmaceutical glass.

The e-Patch offers flexibility in delivery modalities, including:

• Continuous zero-order rate kinetics with 24-hour continuous delivery rates from 0.001 ml/hour to 1.0 ml/minute.
• Flow rates that can be varied over time, pre-programmed to a specific rate profile, and may additionally provide patient-controlled bolus administrations.
• Accommodate pre-filled liquid or lyophilized medications utilizing commonly used materials that can be filled on standard filling equipment.

e-Patch can be used to extend the time-release of drugs with either short half-lives or require frequent and cumbersome dosing regimens. Such drugs can be pre-filled into the e-Patch and delivered to the patient continuously over 24 hours, thus essentially transforming the drug into one with an extended release profile.

• Chronic injectable therapies, including proteins, hormones, antibodies, or small molecules.
• Oral drugs with low bioavailability, narrow therapeutic range or severe gastrointestinal or other side-effects.
• Parenteral drugs with short half-life which would result in improved efficacy as an extended-release profile.
• Injectable drugs with high incidence of site reaction.

• Simple to use, fully disposable.
• Liquid or lyophilized drugs.
• Basal or basal bolus drug delivery profiles.
• Small, lightweight.
• Extensive delivery volume and flow rate options (0.001 ml/hr to 1.0 ml/minute).
• Ability to create extended-release profiles of drugs with short half-lives, without the need for pharmacologic formulation techniques.

1. Remove the e-Patch from its sterile packaging.
2. Remove the backing paper from the adhesive on the bottom of the device.
3. Attach the device on the appropriate body site and depresses the activation button. Pressing the button deploys the floating microprobe into subcutaneous tissue, and activates drug delivery.
4. Upon completion of delivery, press release button that retracts the microprobe back into the e-Patch housing, remove it from the skin, and throw it away. The patient never sees nor handles a needle throughout the process.